General Information
Manufacturer: Genentech
Medical Name: Fabricimab-svoa
Purpose: Vabysmo is a prescription medicine given by injection into the eye used to treat:
- Adults with neovascular (wet) age‑related macular degeneration (AMD),
- Diabetic macular edema (DME), and
- Macular edema following retinal vein occlusion (RVO)
Side Effects
| Side Effect | Description | Percentage |
|---|---|---|
| Conjunctival hemorrhage | Blood on the white of the eye | 7% |
| Cataract | May include blurry vision or seeing halos around lights | 3-15% |
| Eye floaters | Small spots or "strings" floating in your vision | 3% |
| Eye pain | Often occurs within an hour after injection | NA% |
| Increased intraocular pressure | A temporary increase in pressure inside the eye | 3% |
| Retinal tear or retinal pigment epithelial tear | A tear in the retina or the layer underneath it | 3% |
| Vitreous detachment | The gel-like substance in your eye pulls away from the back of the eye | 3% |
Serious but Less Common Side Effects
- Inflammation
- Retinal detachment
- Stroke
- Heart attack
Preclusions To Starting Treatment
- An infection in or around the eye
- Active intraocular inflammation
- Known allergy to faricimab or any of its ingredients)
- Ocular or Periocular Infections: Any infection in or around the eye is a contraindication for Vabysmo treatment.
- Active Intraocular Inflammation: The presence of active swelling, pain, or redness within the eye precludes the use of Vabysmo.
- Hypersensitivity: Patients who have had an allergic reaction to Vabysmo or any of its ingredients should not receive the drug. Allergic reactions may include rash, itching, hives, or severe intraocular inflammation.
Preconditions That Should Be Discussed Before Starting Treatment
| Preclusion | Description |
|---|---|
| Pregnancy and Breastfeeding | Vabysmo may pose a risk to an unborn baby. Females of reproductive potential are advised to use effective contraception during treatment and for at least 3 months after the last dose. It is unknown if Vabysmo passes into breast milk. |
| Risk of Thromboembolic Events | There is a potential risk of blood clot-related issues (such as heart attacks or strokes) with the use of VEGF inhibitors like Vabysmo, though the rate in clinical trials was low. |
| History of certain conditions | Patients with a history of high blood pressure, high cholesterol, or diabetes may have a higher risk of certain side effects (e.g., retinal vascular occlusion). |